For Manhattan plots and other plots where you're plotting -log10(P-values) or untransformed P-values, you sometimes want to draw line to identify when FDR=0.05 is reached. But where do you draw the line? Below is R code that identifies the nearest P-value to FDR=0.05. You can then use variable FDR5.equiv.P to create a line on your Manhattan plot.
Code assumes you have a data frame with two columns, "Pval" and "FDR".