Publication: Sex differences in microRNA expression in first and third trimester human placenta

Sex differences in microRNA expression in first and third trimester human placenta
Biology of Reproduction, 2021 Dec 7, published online ahead of print

• 4 subanalyses of the miRNA-seq cohort in Gonzalez et al. 2021, Epigenomics
• N=113 late first trimester placenta samples from leftover chorionic villus sampling (a prenatal diagnostic test)
• N=47 third trimester placenta samples collected after delivery
• Bulk small RNA-sequencing with a focus on miRNAs
• Sex differences
• First trimester: male vs female placenta
• Third trimester: male vs female placenta
• Sex-specific analysis of first vs third trimester
• Subanalysis of female samples only: first vs third trimester placenta
• Subanalysis of male samples only: first vs third trimester placenta
• Identification of female exclusive and male exclusive gestational changes (miRNAs that change from first to third trimester, but only in one group)

Authors:

Amy E Flowers, Tania L Gonzalez, Nikhil V Joshi, Laura E Eisman, Ekaterina L Clark, Rae A Buttle, Erica Sauro, Rosemarie DiPentino, Yayu Lin, Di Wu, Yizhou Wang, Chintda Santiskulvong, Jie Tang, Bora Lee, Tianyanxin Sun, Jessica L Chan, Erica T Wang, Caroline Jefferies, Kate Lawrenson, Yazhen Zhu, Yalda Afshar, Hsian-Rong Tseng, John Williams, Margareta D Pisarska

PMID: 35040930; DOI: 10.1093/biolre/ioab221